This study shows seipin is essential for recruiting Perilipin-1 to lipid droplets in human adipocytes, maintaining adipocyte identity and preventing de-differentiation.

bioRxiv · Nov 9, 2025 · PreprintCell Biology

PPARγ activation by lipolysis-generated ligands is required for cAMP dependent UCP1 induction in human thermogenic adipocytes

Anand Desai, Zinger Yang Loureiro, Tiffany DeSouza, Qin Yang, Javier Solivan-Rivera, Silvia Corvera

Molecular Metabolism · Oct 23, 2024Peer-reviewedCell Biology

Human Bone Marrow Adipose Tissue is a Hematopoietic Niche for Leptin-DrivenMonopoiesis

Zinger Yang, Amruta Samant, Anand Desai, Tiffany DeSouza, Haley Cirka, Mai Ceesay, David M. Kostyra, Shannon Joyce, Lyne Khair, Javier Solivan-Rivera, Rachel Ziegler, Nathalia Ketelut Carneiro, Linus T Tsai, Michael A. Brehm, Louis M. Messina, , Tammy Nguyen

The paper identifies bone marrow adipose tissue as a hematopoietic niche that drives pro-inflammatory monocyte production via leptin signaling during aging.

bioRxiv · Aug 29, 2023 · PreprintDevelopmental Biology

A Neurogenic Signature Involving Monoamine Oxidase-A controls Human Thermogenic Adipose Tissue Development

Javier Solivan-Rivera, Zinger Yang, Tiffany DeSouza, Anand Desai, Sabine Pallat, Qin Yang, Raziel Rojas-Rodriguez, Rachel Ziegler, Pantos Skritakis, Shannon Joyce, Denise Zhong, Tammy Nguyen, Silvia Corvera

The paper identifies a neurogenic signature involving MAOA that controls human thermogenic adipose tissue development and shows its therapeutic potential for metabolic disease.

eLife · Sep 15, 2022Peer-reviewedDevelopmental Biology

Canonical Wnt Signaling Maintains Human Mesenchymal Progenitor Cell Multipotency During Adipose Tissue Development

Zinger Yang, Shannon Joyce, Javier Solivan-Rivera, Anand Desai, Pantos Skritakis, Qin Yang, Tiffany DeSouza, Tammy Nguyen, Ormond A. MacDougald, Silvia Corvera

bioRxiv · Jul 18, 2022 · PreprintDevelopmental Biology