This study shows seipin is essential for recruiting Perilipin-1 to lipid droplets in human adipocytes, maintaining adipocyte identity and preventing de-differentiation.

bioRxiv · Nov 9, 2025 · PreprintCell Biology

Thermogenic adipocytes alleviate hepatic steatosis and insulin resistance via macrophage cytokine secretion in obese mice

Hui Wang, Mark Kelly, Najihah Aziz, Emmanouela Tsagkaraki, Sarah M. C. Nicoloro, Lawrence M. Lifshitz, Adı́lson Guilherme, Leslie A. Rowland, Batuhan Yenilmez, Kaltinaitis B. Santos, Naideline Raymond, Tiffany DeSouza, Muhammad Tanveer Sajid, Hanna Choi, LAUREN A. TAUER, , Michael Czech

This study shows that adipocyte Nrip1 deficiency in obese mice reduces hepatic steatosis and insulin resistance by promoting M2-like macrophages that secrete IL-1rn.

bioRxiv · Aug 1, 2025 · PreprintPhysiology

PPARγ activation by lipolysis-generated ligands is required for cAMP dependent UCP1 induction in human thermogenic adipocytes

Anand Desai, Zinger Yang Loureiro, Tiffany DeSouza, Qin Yang, Javier Solivan-Rivera, Silvia Corvera

Molecular Metabolism · Oct 23, 2024Peer-reviewedCell Biology

Human Bone Marrow Adipose Tissue is a Hematopoietic Niche for Leptin-DrivenMonopoiesis

Zinger Yang, Amruta Samant, Anand Desai, Tiffany DeSouza, Haley Cirka, Mai Ceesay, David M. Kostyra, Shannon Joyce, Lyne Khair, Javier Solivan-Rivera, Rachel Ziegler, Nathalia Ketelut Carneiro, Linus T Tsai, Michael A. Brehm, Louis M. Messina, , Tammy Nguyen

The paper identifies bone marrow adipose tissue as a hematopoietic niche that drives pro-inflammatory monocyte production via leptin signaling during aging.

bioRxiv · Aug 29, 2023 · PreprintDevelopmental Biology

A Neurogenic Signature Involving Monoamine Oxidase-A controls Human Thermogenic Adipose Tissue Development

Javier Solivan-Rivera, Zinger Yang, Tiffany DeSouza, Anand Desai, Sabine Pallat, Qin Yang, Raziel Rojas-Rodriguez, Rachel Ziegler, Pantos Skritakis, Shannon Joyce, Denise Zhong, Tammy Nguyen, Silvia Corvera

The paper identifies a neurogenic signature involving MAOA that controls human thermogenic adipose tissue development and shows its therapeutic potential for metabolic disease.

eLife · Sep 15, 2022Peer-reviewedDevelopmental Biology

Canonical Wnt Signaling Maintains Human Mesenchymal Progenitor Cell Multipotency During Adipose Tissue Development

Zinger Yang, Shannon Joyce, Javier Solivan-Rivera, Anand Desai, Pantos Skritakis, Qin Yang, Tiffany DeSouza, Tammy Nguyen, Ormond A. MacDougald, Silvia Corvera

bioRxiv · Jul 18, 2022 · PreprintDevelopmental Biology