Zinger Yang

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population

The paper uses single-nuclear RNA sequencing to analyze adipose tissue in lymphedema patients, identifying a stromal cell population that promotes lymphangiogenesis.

Human Bone Marrow Adipose Tissue is a Hematopoietic Niche for Leptin-DrivenMonopoiesis

The paper identifies bone marrow adipose tissue as a hematopoietic niche that drives pro-inflammatory monocyte production via leptin signaling during aging.

A Neurogenic Signature Involving Monoamine Oxidase-A controls Human Thermogenic Adipose Tissue Development

The paper identifies a neurogenic signature involving MAOA that controls human thermogenic adipose tissue development and shows its therapeutic potential for metabolic disease.

Canonical Wnt Signaling Maintains Human Mesenchymal Progenitor Cell Multipotency During Adipose Tissue Development

P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells

This study shows that CRISPR/Cas9 induces toxicity in human pluripotent stem cells, which is dependent on TP53 and hinders genome engineering.