Cancer BiologybioRxivPreprint
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling
Paige V. Halas, Hannah Savage, Stephanie J. Hachey…·Devon A. Lawson
This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.
DOI 10.1101/2025.08.19.670946