Christopher C.W. Hughes

Phagocytosis of SARS-CoV-2 Nucleocapsid- and RNA-Containing Immune Complexes Drives Inflammatory Cytokine Production and Endothelial Dysfunction

This study investigates how SARS-CoV-2 RNA and nucleocapsid-containing immune complexes drive inflammation and endothelial dysfunction through Fcγ receptor and TLR-8 pathways.

ImmuniT Platform for Improved Neoantigen Prediction in Lung Cancer

The paper introduces the ImmuniT platform, which improves neoantigen prediction in lung cancer by identifying more immunogenic targets than conventional methods.

PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling

This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.

CDC42 Inhibitors Alter Patterns of Vessel Arborization in Skin and Tumors in vivo

This study identifies CDC42 inhibitors that reduce vessel branching in both normal skin and tumors, offering potential for treating skin cancer and angiogenesis-related diseases.

Structure-based Design of CDC42 Effector Interaction Inhibitors For the Treatment of Cancer

This paper designs a CDC42 effector interaction inhibitor (ARN22089) that shows anti-cancer activity by blocking tumor invasion and angiogenesis.