Paige V. Halas

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling

This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.

Hidden genomic features of an invasivemalaria vector, Anopheles stephensi

The paper generates a high-quality genome assembly for Anopheles stephensi, identifies novel genomic features, and reveals hidden genetic elements contributing to insecticide resistance and male development.