NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer
Pavla Ticha, Jason J. Northey, Radhika Narain, Shivang Sharma, Johnathon N. Lakins, Hugo Gonzalez, Kelly Kersten, Alastair J. Ironside, Allison P. Drain, Martin Zidek, Kelvin K. Tsai, Yunn‐Yi Chen, Eugene Shenderov, Valerie Marie Weaver
This study identifies NCOR2 as an epigenetic repressor of MHC class I expression in breast cancer, promoting metastasis by inhibiting immune surveillance.
Nature Communications · May 5, 2026Peer-reviewedCancer Biology