Very long chain fatty acids drive 1-deoxy-Sphingolipid toxicity
Adam Majcher, Gergely Karsai, Elkhan Yusifov, Martina Schaettin, Ermanno Malagola, Péter Horváth, Jinmei Li, Maftuna Shamshiddinova, Gai Zhibo, Raghvendra Dubey, Timothy R. Peterson, Sofía Rodriguez-Gallardo, Kuniyoshi Shimizu, 武士 原山, Thorsten Hornemann
This study identifies VLC fatty acids as mediators of 1-deoxySL toxicity through mitochondrial dysfunction and BAX-dependent apoptosis.
bioRxiv · May 13, 2025 · PreprintBiochemistry