Author

Gergely Karsai

University of ZurichORCID 0000-0002-6840-682XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Thorsten HornemanniD· 3 shared Francesco PaneniiD· 2 shared Frank Thomas RuschitzkaiD· 2 shared Adam Majcher· 1 shared Alaa OthmaniD· 1 shared Alessandro MengozziiD· 1 shared Benjamin HänischiD· 1 shared Cordula KnoppiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

Thorsten HornemannORCID

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Author profile →

4 papers

Recent·Most cited

Very long chain fatty acids drive 1-deoxy-Sphingolipid toxicity

Adam Majcher, Gergely Karsai, Elkhan Yusifov, Martina Schaettin, Ermanno Malagola, Péter Horváth, Jinmei Li, Maftuna Shamshiddinova, Gai Zhibo, Raghvendra Dubey, Timothy R. Peterson, Sofía Rodriguez-Gallardo, Kuniyoshi Shimizu, 武士原山, Thorsten Hornemann

This study identifies VLC fatty acids as mediators of 1-deoxySL toxicity through mitochondrial dysfunction and BAX-dependent apoptosis.

bioRxiv · May 13, 2025 · PreprintBiochemistry

Chromatin Remodeling by the Histone Methyltransferase SETD2 Drives Lipotoxic Injury in Cardiometabolic Heart Failure with Preserved Ejection Fraction

Sarah Costantino, S. A. Mohammed, Samuele Ambrosini, Marialucia Telesca, Alessandro Mengozzi, Kaivalya Walavalkar, Era Gorica, Melissa Herwig, Loek van Heerebeek, Junyan Xia, Gergely Karsai, Thorsten Hornemann, Omer Dzemali, Raffaella Santoro, Qian Lin, , Francesco Paneni

This study shows that SETD2 promotes lipotoxic injury in cHFpEF by regulating SREBP1 and lipid metabolism, and its inhibition improves cardiac function.

Circulation Research · Apr 11, 2025Peer-reviewedPhysiology

AQP1 Differentially Orchestrates Endothelial Cell Senescence

Khatereh Shabanian, Taraneh Shabanian, Gergely Karsai, Luca Pontiggia, Francesco Paneni, Frank Ruschitzka, Jürg H Beer, Seyed Soheil Saeedi Saravi

This study identifies AQP1 as a regulator of endothelial cell senescence and angiogenesis, showing its dual role in proliferating and senescent cells through modulation of the HDAC4-Mef2A pathway.

bioRxiv · Mar 13, 2024Molecular Biology

Aberrant DEGS1 sphingolipid metabolism impairs central and peripheral nervous system function in humans

Gergely Karsai, Florian Kraft, Natja Haag, Georg Christoph Korenke, Benjamin Hänisch, Alaa Othman, Saranya Suriyanarayanan, R. Steiner, Cordula Knopp, Michael Mull, Markus Bergmann, J. M. Schröder, Joachim Weis, Miriam Elbracht, Matthias Begemann, , Ingo Kurth

This study identifies a DEGS1 mutation causing sphingolipid metabolism defects, leading to neurological disorders and suggests dietary intervention as a potential treatment.

Journal of Clinical Investigation · Jan 8, 2019Peer-reviewedGenetics