Timothy R. Peterson

NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx

The paper shows Tmem178 suppresses NLRP3 inflammasome activation in osteoclasts by limiting calcium release, preventing excessive bone resorption.

Very long chain fatty acids drive 1-deoxy-Sphingolipid toxicity

This study identifies VLC fatty acids as mediators of 1-deoxySL toxicity through mitochondrial dysfunction and BAX-dependent apoptosis.

Cell fitness is an omniphenotype

The paper proposes using cell fitness as a universal phenotype to prioritize gene and drug targets in disease research, showing its broad applicability across diseases and cost-effectiveness.

A dual MTOR/NAD+ acting gerotherapy

This paper identifies BIOIO-1001 as a dual mTOR/NAD+ acting gerotherapy that reduces metabolic derangements, inflammation, and fibrosis in NASH and ALS models.

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.

The paper identifies ATRAID as a gene critical for the response to nitrogen-containing bisphosphonates, showing its role in drug efficacy and resistance in osteoporosis.

Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens

This study identifies that multiple cationic amphipathic drugs (CADs) share molecular similarities with chloroquine and inhibit sphingolipid biosynthesis, suggesting their potential as antiviral agents against diverse pathogens including SARS-CoV-2.