Cell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro
Teodora Piskova, Aleksandra N. Kozyrina, Giedre Astrauskaite, Mohamed H. Elsafi Mabrouk, Sebastian Schepl, Stacy Lok Sze Yam, Ragul Ravithas, Wolfgang Wagner, Massimo Vassalli, Jacopo Di Russo
The paper shows that cell loss in RPE cells leads to mechanical changes that impair function, mimicking age-related decline in an in vitro model.
Nature Communications · Apr 8, 2026Peer-reviewedCell Biology