Aleksandra N. Kozyrina

The paper shows that cell loss in RPE cells leads to mechanical changes that impair function, mimicking age-related decline in an in vitro model.

This study investigates how nucleoli drive nuclear remodelling in cardiomyocytes during heart failure, showing NI loss precedes cytoskeletal stiffening and is linked to DNA damage and nucleolar changes.

This paper develops a photodegradable hydrogel to model age-related ECM deformation, showing that artificial drusen size affects retinal pigment epithelium morphology without disrupting actin cytoskeleton or polarity.