Targeting Histamine H3 Receptors to Suppress NGF-Driven Hyperexcitability in Neuropathic Pain
Ajeet Kumar, Rakesh Kumar, Poonam Kumari, Aditi Bagade, Anjali Yadav, Boda Arun Kumar, Shalini Dogra, Deepmala Umrao, Bryan A. Copits, Charles F. Zorumski, Steven J. Mennerick, Prem Narayan Yadav
This study investigates the role of H3R in DRG neurons and shows that an H3R inverse agonist reduces mechanical hypersensitivity in neuropathic pain without affecting thermal pain.
bioRxiv · Sep 3, 2026 · PreprintNeuroscience