Steven J. Mennerick

Targeting Histamine H3 Receptors to Suppress NGF-Driven Hyperexcitability in Neuropathic Pain

This study investigates the role of H3R in DRG neurons and shows that an H3R inverse agonist reduces mechanical hypersensitivity in neuropathic pain without affecting thermal pain.

Subunit selective modulation of GABAA receptors using pharmacogenetically tethered neurosteroids

The paper develops a DART platform to selectively modulate GABAA receptor subunits using neurosteroids, identifying C11-linked compounds that enhance GABA currents in 4/{delta}-containing receptors.

A Non-Classical Neuroactive Steroid Exhibiting Potent, Efficacious GABA A Receptor Agonism and NMDA Receptor Inhibition

This paper characterizes YX84, a novel neuroactive steroid with dual GABA A receptor agonism and NMDA receptor inhibition, showing favorable behavioral tolerability.

VDAC activation inhibits hippocampal plasticity via NLRP3 inflammasome & caspase-1: modulation by allopregnanolone enantiomers

This study shows that VDAC activation by erastin inhibits hippocampal long-term potentiation and memory formation, effects that are prevented by allopregnanolone and its enantiomer.

A role for δ subunit-containing GABA-A receptors on parvalbumin positive neurons in maintaining electrocortical signatures of sleep states

The paper investigates the role of δ subunit-containing GABA-A receptors on parvalbumin positive neurons in shaping electrocortical activity during sleep states, finding altered EEG patterns in their absence.

Multifaceted Actions of Neurosteroids

The paper investigates the range of actions of neurosteroid analogues using in silico and in vitro methods, revealing unexpected modulation of multiple targets beyond GABA-A receptors.

Sertraline modulates hippocampal plasticity and learning via sigma 1 receptors, cellular stress and neurosteroids

This study investigates how sertraline affects hippocampal plasticity and learning through sigma 1 receptors, cellular stress, and neurosteroids in rat models.

Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming

This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.

δ-containing GABAA receptors on parvalbumin interneurons modulate neuronal excitability and network dynamics in the mouse medial prefrontal cortex

This study shows that δ-containing GABAA receptors in PV interneurons regulate their excitability and inhibit pyramidal neurons in the mPFC, affecting network dynamics.

Periodic and aperiodic changes to cortical EEG in response to pharmacological manipulation

The paper examines how pharmacological manipulations affect the aperiodic exponent of EEG power spectra in mice, finding it is not a reliable marker of excitation/inhibition balance.

Chronic striatal cholinergic interneuron excitation induces clinically-relevant dystonic behavior in mice

Chronic excitation of striatal cholinergic interneurons in mice induces clinically-relevant dystonic leg adduction variability, supporting their role in dystonia and suggesting therapeutic targets.

Cornichon Homolog-3 (CNIH3) Modulates Spatial Memory in Female Mice

This study investigates the role of CNIH3 in spatial memory, finding sex-specific effects where CNIH3 deficiency impairs spatial memory in female mice but not males.