PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes
Gordana Wutz, Iain F. Davidson, Edward J. Banigan, Roman R. Stocsits, Ryotaro Kawasumi, Wen Tang, Kota Nagasaka, Lorenzo Costantino, Ralf Jansen, Kouji Hirota, Dana Branzei, Leonid A. Mirny, Jan‐Michael Peters
This study shows PDS5 proteins regulate genome architecture by stopping loop extrusion and strengthening CTCF boundaries through NIPBL dissociation from cohesin.
Molecular Cell · Apr 23, 2026Peer-reviewedMolecular Biology