Roman R. Stocsits

PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes

This study shows PDS5 proteins regulate genome architecture by stopping loop extrusion and strengthening CTCF boundaries through NIPBL dissociation from cohesin.

Cohesin supercoils DNA during loop extrusion

This study shows cohesin supercoils DNA during loop extrusion, influencing genome architecture through both looping and supercoiling.

HiCognition: a visual exploration and hypothesis testing tool for 3D genomics

HiCognition enables visual exploration and hypothesis testing of 3D genomic structure by integrating 1D genomics profiles and machine learning.

Transcription shapes 3D chromatin organization by interacting with loop extrusion

The paper shows that transcribing RNA polymerases act as moving barriers to cohesin, altering chromatin organization near active genes.

Cohesin-dependent and independent mechanisms support chromosomal contacts between promoters and enhancers

The paper investigates chromosomal contacts between promoters and enhancers using Capture Hi-C, showing that cohesin depletion affects long-range contacts but not shorter-range ones.

CTCF, WAPL and PDS5 proteins control the formation of TADs and loops by cohesin

This study demonstrates that CTCF, WAPL, and PDS5 proteins regulate TADs and loops by controlling cohesin's interaction with chromatin.