Dana Branzei

PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes

This study shows PDS5 proteins regulate genome architecture by stopping loop extrusion and strengthening CTCF boundaries through NIPBL dissociation from cohesin.

FANCJ DNA helicase is recruited to the replisome by AND-1 to ensure genome stability

This study identifies FANCJ's interaction with AND-1 as critical for replisome recruitment and genome stability, showing that mutations in the CIP box impair this function and contribute to cancer risk.

Timeless couples G quadruplex detection with processing by DDX11 during DNA replication

The paper identifies a G quadruplex binding domain in Timeless and shows its collaboration with DDX11 to process G4 structures during DNA replication.