Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum
Christopher G. Jacob, Megan R. Ansbro, Roberto Amato, Mihir Kekre, Ranitha Vongpromek, Mehul Dhorda, Chanaki Amaratunga, Sokunthea Sreng, Seila Suon, Olivo Miotto, Rick M. Fairhurst, Thomas E. Wellems, Dominic P. Kwiatkowski
The paper develops and validates PCR assays to detect plasmepsin 2/3 and pfmdr1 copy number variations in Plasmodium falciparum field isolates, finding increasing plasmepsin 2/3 duplications and loss of pfmdr1 mutations in Cambodia.
Malaria Journal · May 13, 2020Peer-reviewedGenetics