Olivo Miotto

Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa

The paper analyzes the evolution and prevalence of dhfr and dhps resistance alleles and haplotypes across Africa using whole genome data from multiple countries.

A complex Plasmodium falciparum cryptotype circulating at low frequency across the African continent

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.

A molecular barcode and online tool to identify and map imported infection with Plasmodium vivax

The paper develops a molecular barcode and online tool to identify and map imported Plasmodium vivax infections using SNP analysis and machine learning.

The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.

The paper identifies a transcriptional profile in artemisinin-resistant Plasmodium falciparum that originates from initial drug responses and involves proteotoxic stress and REDOX metabolism.

Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

The paper develops and validates PCR assays to detect plasmepsin 2/3 and pfmdr1 copy number variations in Plasmodium falciparum field isolates, finding increasing plasmepsin 2/3 duplications and loss of pfmdr1 mutations in Cambodia.

Genomic epidemiology of the current wave of artemisinin resistant malaria

This study identifies kelch13 mutations associated with artemisinin resistance in Southeast Asia and finds low frequency of these mutations in Africa, suggesting different evolutionary pressures.