Cholesterol remodels the endoplasmic reticulum to control myofibroblastic CAF function
Srimayee Vaidyanathan, Nicole Laurencia Yuwono, Ellie T. Y. Mok, Jessica L. Chitty, Jesse A. Rudd-Schmidt, Riley A Goldsworthy, Rasan M Sathiqu, Andrew Graham Cox, Thomas R. Cox, Kristin Brown
This study shows that cholesterol biosynthesis is critical for myofibroblastic CAFs to remodel the extracellular matrix and promote tumor metastasis.
bioRxiv · Feb 17, 2026 · PreprintCell Biology