Multispecific nanobody degraders co-deplete membrane receptors and enable targeted delivery of diverse payloads
Md Kabir, Yong Joon (Jeffrey) Kim, Zhijie Deng, Yufei Xiang, Paul R. Sargunas, Nuozi Song, Zishan Wang, Nesteene Joy Param, Changzhong Jin, Zhe Sang, Alicia Yue, Alba Bundo, Razeen Hossain, Yue Zhong, Yindan Lin, , Yi Shi
This paper develops MINDS, a multispecific nanobody-Fc platform that co-depletes membrane receptors and delivers diverse payloads, showing improved antitumor activity in cancer models.
bioRxiv · May 6, 2026 · PreprintCancer Biology