Yufei Xiang

Multivalent Nanobodies for Potent and Broad Neutralization of Staphylococcus aureus Toxins

This paper develops multivalent nanobodies that neutralize multiple S. aureus toxins, showing potent activity in murine models of sepsis and pneumonia.

Multispecific nanobody degraders co-deplete membrane receptors and enable targeted delivery of diverse payloads

This paper develops MINDS, a multispecific nanobody-Fc platform that co-depletes membrane receptors and delivers diverse payloads, showing improved antitumor activity in cancer models.

One Thousand SARS-CoV-2 Antibody Structures Reveal Convergent Binding and Near-Universal Immune Escape

The paper analyzes 1,100 SARS-CoV-2 antibody structures to show convergent paratope structures and near-universal immune escape by advanced variants.

Spt6 directly interacts with Cdc73 and is required for Paf1C recruitment to active genes

The paper identifies a direct interaction between Cdc73 and Spt6, showing Spt6 is required for Paf1C recruitment to active genes in yeast.

Llamanade: an open-source computational pipeline for robust nanobody humanization

Llamanade is an open-source pipeline that humanizes nanobodies using sequence and structural analysis, improving their translational potential for therapeutic applications.

Cross-linking/Mass Spectrometry: A Community-Wide, Comparative Study Towards Establishing Best Practice Guidelines

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.