Author
Icahn School of Medicine at Mount SinaiORCID 0000-0002-1516-2796Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Y S Kim, Nicholas R. Walton, Wei Huang…·Yi Shi
This paper develops multivalent nanobodies that neutralize multiple S. aureus toxins, showing potent activity in murine models of sepsis and pneumonia.
Md Kabir, Yong Joon (Jeffrey) Kim, Zhijie Deng…·Yi Shi
This paper develops MINDS, a multispecific nanobody-Fc platform that co-depletes membrane receptors and delivers diverse payloads, showing improved antitumor activity in cancer models.
Zirui Feng, Zhe Sang, Yufei Xiang…·Yi Shi
The paper analyzes 1,100 SARS-CoV-2 antibody structures to show convergent paratope structures and near-universal immune escape by advanced variants.
Zhe Sang, Yufei Xiang, İvet Bahar, Yi Shi
Llamanade is an open-source pipeline that humanizes nanobodies using sequence and structural analysis, improving their translational potential for therapeutic applications.