Author

Nesteene Joy Param

Icahn School of Medicine at Mount SinaiORCID 0000-0002-4276-7563Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Alba Bundo· 1 shared Alicia Yue· 1 shared Changzhong Jin· 1 shared Ernesto GuccioneiD· 1 shared Jian Jun JiniD· 1 shared Kuan-lin HuangiD· 1 shared Md Kabir· 1 shared Mingye FengiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alba Bundo

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1 paper

Recent·Most cited

Multispecific nanobody degraders co-deplete membrane receptors and enable targeted delivery of diverse payloads

Md Kabir, Yong Joon (Jeffrey) Kim, Zhijie Deng, Yufei Xiang, Paul R. Sargunas, Nuozi Song, Zishan Wang, Nesteene Joy Param, Changzhong Jin, Zhe Sang, Alicia Yue, Alba Bundo, Razeen Hossain, Yue Zhong, Yindan Lin, , Yi Shi

This paper develops MINDS, a multispecific nanobody-Fc platform that co-depletes membrane receptors and delivers diverse payloads, showing improved antitumor activity in cancer models.

bioRxiv · May 6, 2026 · PreprintCancer Biology