Author

Reed Lessing

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Albert R. La SpadaiD· 1 shared Çağla EroğluiD· 1 shared Christabel Xin TaniD· 1 shared Dhanesh Sivadasan BinduiD· 1 shared Gabrielle M. SejourneiD· 1 shared Jessica L. MooreiD· 1 shared Kristina SakersiD· 1 shared Kylie Dimond· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Albert R. La SpadaORCID

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1 paper

Recent·Most cited

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

Shiyi Wang, Ryan Baumert, Gabrielle M. Sejourne, Dhanesh Sivadasan Bindu, Kylie Dimond, Kristina Sakers, Leslie Vazquez, Jessica L. Moore, Christabel Xin Tan, Tetsuya Takano, Maria Pia Rodriguez, Nick Brose, Luke Bradley, Reed Lessing, Scott H. Soderling, , Çağla Eroğlu

This study shows that the LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance by hyperphosphorylating ERM proteins, which disrupts the Ezrin/Atg7 interaction and autophagy.

bioRxiv · Apr 9, 2023 · PreprintNeuroscience