Author

Nicholas Brose

Duke Medical CenterORCID 0000-0003-1559-0237Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Çağla EroğluiD· 2 shared Christabel Xin TaniD· 2 shared Dhanesh Sivadasan BinduiD· 2 shared Kylie Dimond· 2 shared Luke BradleyiD· 2 shared Albert R. La SpadaiD· 1 shared Gabrielle M. SejourneiD· 1 shared Jessica L. MooreiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Çağla EroğluORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 9, 2023

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

Shiyi Wang, Ryan Baumert, Gabrielle M. Sejourne…·Çağla Eroğlu

This study shows that the LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance by hyperphosphorylating ERM proteins, which disrupts the Ezrin/Atg7 interaction and autophagy.

2 citations

mousestatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 17, 2023

GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes

Dhanesh Sivadasan Bindu, Justin T Savage, Nicholas Brose…·Çağla Eroğlu

The paper introduces GEARBOCS, an AAV-based CRISPR/Cas9 tool for in vivo astrocyte gene editing, demonstrating its utility for knockout, tagging, and reporter knock-in strategies in mice.

9 citations

mouseexperimental assay

𝕏 PostBluesky