Dhanesh Sivadasan Bindu

This study identifies Neurocan as an astrocyte-secreted protein that promotes inhibitory synapse formation and function through its C-terminal fragment.

This study shows that TSP1 and TSP2 from astrocytes are essential for synapse development and effort control during operant conditioning in mice.

This study shows that the LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance by hyperphosphorylating ERM proteins, which disrupts the Ezrin/Atg7 interaction and autophagy.

The paper introduces GEARBOCS, an AAV-based CRISPR/Cas9 tool for in vivo astrocyte gene editing, demonstrating its utility for knockout, tagging, and reporter knock-in strategies in mice.