Author

Kylie Dimond

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Çağla EroğluiD· 2 shared Christabel Xin TaniD· 2 shared Dhanesh Sivadasan BinduiD· 2 shared Luke BradleyiD· 2 shared Nicholas BroseiD· 2 shared Albert R. La SpadaiD· 1 shared Gabrielle M. SejourneiD· 1 shared Jessica L. MooreiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Çağla EroğluORCID

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2 papers

Recent·Most cited

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

Shiyi Wang, Ryan Baumert, Gabrielle M. Sejourne, Dhanesh Sivadasan Bindu, Kylie Dimond, Kristina Sakers, Leslie Vazquez, Jessica L. Moore, Christabel Xin Tan, Tetsuya Takano, Maria Pia Rodriguez, Nick Brose, Luke Bradley, Reed Lessing, Scott H. Soderling, , Çağla Eroğlu

This study shows that the LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance by hyperphosphorylating ERM proteins, which disrupts the Ezrin/Atg7 interaction and autophagy.

bioRxiv · Apr 9, 2023 · PreprintNeuroscience

GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes

Dhanesh Sivadasan Bindu, Justin T Savage, Nicholas Brose, Luke Bradley, Kylie Dimond, Christabel Xin Tan, Çağla Eroğlu

The paper introduces GEARBOCS, an AAV-based CRISPR/Cas9 tool for in vivo astrocyte gene editing, demonstrating its utility for knockout, tagging, and reporter knock-in strategies in mice.

bioRxiv · Jan 17, 2023 · PreprintNeuroscience