Gabrielle M. Sejourne

This study shows that δ-catenin regulates astrocyte transcriptional maturation and circuit stabilization via Zbtb20, with loss of δ-catenin disrupting layer-specific astrocyte identities and prolonging ocular dominance plasticity.

The paper uses physical gel models and simulations to study brain folding in ferrets and links findings to human cortical malformations caused by genetic defects.

This study shows that mitochondrial fission is essential for astrocyte morphogenesis and organization in the cortex, with Drp1 loss causing morphological and functional deficits.

This study shows that the LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance by hyperphosphorylating ERM proteins, which disrupts the Ezrin/Atg7 interaction and autophagy.