The Gp78 ubiquitin E3 ligase drives mitophagy by regulating omegasome formation
Milene Ortiz‐Silva, Bharat Joshi, Jerry Zheng, Ren Takimoto, Sanchit Chopra, Nozomu Yachie, Ghassan Hamarneh, Ivan R. Nabi
This study shows Gp78 ubiquitin ligase regulates omegasome formation and mitochondrial protein degradation during mitophagy, independent of PINK1 and Parkin.
bioRxiv · Sep 7, 2026 · PreprintCell Biology