Gelsolin protects mitochondria and regulates inflammation during Legionella pneumophila infection
Owen D. Whitham, Mostafa M. Eltobgy, Mohamed M. Shamseldin, Asmaa Badr, Richard A Perez, Yara Y. Hassan, Heba M. Amer, Gauruv A. Gupta, Sarah E. Faber, Frank H. Robledo-Avila, Xiaoli Zhang, Maya Mikami, Santiago Partida‐Sánchez, Stephanie M. Seveau, Amal O. Amer
This study shows that gelsolin protects against Legionella pneumophila infection by maintaining mitochondrial health, reducing inflammation, and supporting neutrophil function.
bioRxiv · Aug 20, 2026 · PreprintImmunology