Author

Mohamed M. Shamseldin

The Ohio State UniversityORCID 0000-0002-5324-1145Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Amal O. AmeriD· 3 shared Asmaa BadriD· 3 shared Gauruv A. Gupta· 3 shared Heba M. AmeriD· 3 shared Mostafa M. EltobgyiD· 3 shared Owen D. Whitham· 3 shared Xiaoli ZhangiD· 3 shared Amy WebbiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

Amal O. AmerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologyJCI InsightPeer-reviewedSep 21, 2026

Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection

Mostafa M. Eltobgy, Mohamed M. Shamseldin, Owen D. Whitham…·Amal O. Amer

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

1 citation

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintAug 20, 2026

Gelsolin protects mitochondria and regulates inflammation during Legionella pneumophila infection

Owen D. Whitham, Mostafa M. Eltobgy, Mohamed M. Shamseldin…·Amal O. Amer

This study shows that gelsolin protects against Legionella pneumophila infection by maintaining mitochondrial health, reducing inflammation, and supporting neutrophil function.

DOI 10.64898/2026.08.17.745205

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 14, 2025

AI-based decoding of long covid cognitive impairments in mice using automated behavioral system and comparative transcriptomic analysis

Heba M. Amer, Mohamed M. Shamseldin, Sarah Faber…·Amal O. Amer

This study uses an automated behavioral system and transcriptomic analysis to identify cognitive impairments in mice with long COVID, finding similar transcriptomic changes to humans.

DOI 10.1101/2025.05.14.654036

mousebulk RNA-seq

𝕏 PostBluesky