Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.
Zhengping Shao, Brian J. Lee, Hanwen Zhang, Xiaohui Lin, Chen Li, Wenxia Jiang, Napon Chirathivat, Steven Gershik, Michael M. Shen, Richard J. Baer, Shan Zha
This study shows that catalytically inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner, revealing its severe impact on normal tissues.
Proceedings of the National Academy of Sciences · Jul 24, 2023Peer-reviewedGenetics