Aspartate transaminases are required for blood development
Narges Pourmandi, Greggory Myers, Arjun Jha, Kelsey Temprine, Amanda D. Sankar, Nupur Kanti Das, Ridwana Khan, Siva Kumar Natarajan, Cristina Castillo, Peter Sajjakulnukit, Noah S. Nelson, Matthew D. Perricone, Indrani Talukder, Aaron D. denDekker, Lin Lin, , Costas Andreas Lyssiotis
This study identifies aspartate transaminases GOT1 and GOT2 as critical for erythropoiesis by linking metabolism to epigenetic regulation, revealing a novel role in blood development.
bioRxiv · Sep 16, 2025 · PreprintBiochemistry