Author

Siva Kumar Natarajan

University of MichiganORCID 0000-0002-9663-079XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aaron D. denDekkeriD· 1 shared Aaron Y. MochizukiiD· 1 shared Alberto DelaidelliiD· 1 shared Amanda D. Sankar· 1 shared Andrew M. DonsoniD· 1 shared Antonio C.T. Cobos· 1 shared Arjun Jha· 1 shared Baoli HuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Aaron D. denDekkerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Adenosylhomocysteinase drives epigenetic and metabolic reprogramming in ZFTA-RELA ependymoma

Navneesh Yadav, Olivia Pelcher, Raja Gopal Reddy Mooli, Robert B Cameron, Alberto Delaidelli, Kannan Boosi Narayana Rao, Bhagyalakshmi Manikandan, Senna Visser, Antonio C.T. Cobos, Vishal Parmar, Yuvraj Kayola, Siva Kumar Natarajan, Yash Patel, Jiao Zhang, Hardik Shah, , Kulandaimanuvel Antony Michealraj

This study identifies AHCY as a key driver of epigenetic and metabolic reprogramming in ZFTA-RELA ependymomas, revealing its role in promoting tumor growth through pyrimidine synthesis and asparagine dependency.

bioRxiv · Oct 7, 2026 · PreprintCancer Biology

Aspartate transaminases are required for blood development

Narges Pourmandi, Greggory Myers, Arjun Jha, Kelsey Temprine, Amanda D. Sankar, Nupur Kanti Das, Ridwana Khan, Siva Kumar Natarajan, Cristina Castillo, Peter Sajjakulnukit, Noah S. Nelson, Matthew D. Perricone, Indrani Talukder, Aaron D. denDekker, Lin Lin, , Costas Andreas Lyssiotis

This study identifies aspartate transaminases GOT1 and GOT2 as critical for erythropoiesis by linking metabolism to epigenetic regulation, revealing a novel role in blood development.

bioRxiv · Sep 16, 2025 · PreprintBiochemistry