Matthew D. Perricone

This study shows that combining CD73 inhibition with immune-stimulatory gene therapy improves treatment efficacy for wtIDH1 gliomas.

This study shows that ferroptosis in pancreatic cancer cells induces both pro- and anti-inflammatory signals, creating an immunosuppressive tumor microenvironment in mouse models.

This study investigates the role of aspartate transaminases in pancreatic development and cancer progression using conditional knockout mice, finding that their loss does not affect tumor growth but impacts pancreas size in double knockout models.

This study identifies aspartate transaminases GOT1 and GOT2 as critical for erythropoiesis by linking metabolism to epigenetic regulation, revealing a novel role in blood development.