Integrating Segmental Deuteration iCM-SANS with SAXS and MD for Dynamical Analysis of Multi-domain Proteins
Aya Okuda, Rintaro Inoue, Minami Kurokawa, Anne Martel, Lionel Porcar, Rikuto Osaki, Kaori Fukuzawa, Kevin L. Weiss, Sai Venkatesh Pingali, Reiko Urade, Masaaki Sugiyama
The paper develops a protocol combining segmental deuteration and multi-step protein ligation with SAXS and iCM-SANS to improve discrimination of conformational ensembles in multi-domain proteins.
bioRxiv · Feb 27, 2026 · PreprintBiophysics