Immune receptor LILRB1 mediates cis-signalling which is targeted by RIFINs of the malaria parasite
Samuel G. Chamberlain, Marcus A. Widdess, Alexander M. Mørch, Akihito Sakoguchi, Rina Sakuno, Elke Kurz, Lina Chen, Salvatore Valvo, Shiroh Iwanaga, Michael Loran Dustin, Matthew K. Higgins
The paper shows RIFINs of Plasmodium falciparum bind LILRB1 in different conformations, triggering inhibitory signaling either in trans or cis to suppress immune responses.
bioRxiv · Apr 17, 2026 · PreprintMicrobiology