Shiroh Iwanaga

Transcriptional repression by AP2-Sp3 regulates the mosquito-to-mammal infectivity switch in malaria sporozoites

This study identifies AP2-Sp3 as a transcriptional repressor that maintains midgut sporozoite identity and controls the mosquito-to-mammal infectivity switch in malaria parasites.

Immune receptor LILRB1 mediates cis-signalling which is targeted by RIFINs of the malaria parasite

The paper shows RIFINs of Plasmodium falciparum bind LILRB1 in different conformations, triggering inhibitory signaling either in trans or cis to suppress immune responses.

Precise regulation of gene expression through transcriptional repression is essential for Plasmodium asexual blood stage development

This study identifies PbAP2-TR as a transcriptional repressor essential for Plasmodium berghei asexual blood stage development by regulating gene expression during trophozoite stage.

RIFINs displayed on malaria-infected erythrocytes bind both KIR2DL1 and KIR2DS1

The paper identifies RIFINs that bind both inhibitory and activating KIR receptors, revealing their role in modulating NK cell activation during malaria infection.

Raman flow cytometry using time delay integration

This paper introduces a Raman flow cytometry system using time-delay integration and dual-sided line illumination, achieving high throughput for cell and particle detection.

Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei

This paper develops a new Plasmodium berghei parasite line with constitutive Cas9 and inducible Cre recombinase for conditional gene editing, demonstrating its use in knocking out the CLAMP gene.

gARID-associated chromatin remodeling events are essential for gametocyte development in Plasmodium

This study shows that gARID is essential for gametocyte development in Plasmodium by participating in two chromatin remodeling events critical for both male and female gametocytes.