Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
Amrita A. Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M. McGovern, Lisa A. Beyer, Hongyuan Zhang, Hsin‐I Jen, Rizwan Yousaf, Onur Birol, Jenny Jia Sun, Russell Scott Ray, Yehoash Raphael, Neil Segil, Andrew K. Groves
This study shows that reprogramming mature mammalian cochlear cells with ATOH1, GFI1, and POU4F3 is hindered by epigenetic inaccessibility and cell-cell signaling, particularly Notch signaling.
eLife · Nov 17, 2022Peer-reviewedDevelopmental Biology