Yehoash Raphael

The paper constructs a cross-species single-cell transcriptomic atlas of hair cells across multiple vertebrates and identifies conserved and species-specific gene expression programs.

This study creates a rabbit model with USH2A mutations causing hearing loss and progressive retinal degeneration, mimicking human Usher Syndrome.

This study shows that reprogramming mature mammalian cochlear cells with ATOH1, GFI1, and POU4F3 is hindered by epigenetic inaccessibility and cell-cell signaling, particularly Notch signaling.