Author

Tiantian Cai

Baylor College of MedicineORCID 0000-0002-0140-8329Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Amrita A. IyeriD· 1 shared Andrew K. GrovesiD· 1 shared Angela ChouiD· 1 shared Asma Lasram· 1 shared Christoph PollmanniD· 1 shared Giray EnkaviiD· 1 shared Hongyuan ZhangiD· 1 shared Hsin‐I Jen· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperDevelopmental Biology

Amrita A. IyerORCID

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2 papers

Recent·Most cited

Structural Rewiring of IL-7R Dimerization by an Oncogenic Transmembrane Mutation Can Be Reversed by Rational Design

Qian Wang, Min Chen, Asma Lasram, Saana Vihuri, Angela Chou, Weixin Bian, Zhiming Dai, Outi Haapanen, Giray Enkavi, Christoph Pollmann, Ilpo Vattulainen, Tiantian Cai, Jacob Piehler, James Jeiwen Chou

This study identifies an oncogenic TMD mutation in IL-7R that causes ligand-independent signaling and shows that rationally designed transmembrane helices can reverse this effect.

Proceedings of the National Academy of Sciences · Apr 28, 2026Peer-reviewedBiophysics

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

Amrita A. Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M. McGovern, Lisa A. Beyer, Hongyuan Zhang, Hsin‐I Jen, Rizwan Yousaf, Onur Birol, Jenny Jia Sun, Russell Scott Ray, Yehoash Raphael, Neil Segil, Andrew K. Groves

This study shows that reprogramming mature mammalian cochlear cells with ATOH1, GFI1, and POU4F3 is hindered by epigenetic inaccessibility and cell-cell signaling, particularly Notch signaling.

eLife · Nov 17, 2022Peer-reviewedDevelopmental Biology