A comprehensive view of somatic mosaicism by single-cell DNA analysis
Lovelace J. Luquette, Tim H. H. Coorens, Abhiram Natu, Milovan Šuvakov, Ann H. Caplin, Mee Sook Jun, Alisa Mo, Joe Pelt, Lisa Anderson, Michele Berselli, Sravya Venkata Bhamidipati, Thomas P. Blanchard, Joseph Brew, Hye-Jung E. Chun, Hyunbin Chun, , Alexej S. Abyzov
The paper uses single-cell DNA sequencing to analyze somatic mosaicism in postmortem lung and colon tissues, revealing mutation heterogeneity, chromosomal abnormalities, and cellular ancestry.
bioRxiv · Oct 31, 2025 · PreprintGenomics