Author

Robert I. Menzies

AstraZeneca (Sweden)

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Molecular Biology· 1

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Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

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Ákos VégváriiD· 1 shared Alexander Georg NickeliD· 1 shared Andrea DegasperiiD· 1 shared Anna WalentinssoniD· 1 shared Christer BetsholtziD· 1 shared Christoph MaackiD· 1 shared Claus BendtseniD· 1 shared Dominique KoppenhöferiD· 1 shared

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1 shared paperMolecular Biology

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1 paper

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedMar 20, 2024

Epigenetic modulators link mitochondrial redox homeostasis to cardiac function

Zaher Elbeck, Mohammad Bakhtiar Hossain, Humam Siga…·Christer Betsholtz

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.

15 citations

mousehuman

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