Molecular BiologyNature CommunicationsPeer-reviewed
Epigenetic modulators link mitochondrial redox homeostasis to cardiac function
Zaher Elbeck, Mohammad Bakhtiar Hossain, Humam Siga…·Christer Betsholtz
The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.