Exacerbation of influenza virus induced lung injury by alveolar macrophages and its suppression by pyroptosis blockade in a human lung alveolus chip
Yuncheng Man, Yunhao Zhai, Amanda R. Jiang, Haiqing Bai, Aakanksha Gulati, Roberto Plebani, Robert J. Mannix, Gwenn E. Merry, Girija Goyal, Chaitra Belgur, Sean R. R. Hall, Donald E. Ingber
This study shows that alveolar macrophages worsen influenza-induced lung injury in a human lung alveolus chip, but blocking pyroptosis reduces inflammation and tissue damage.
bioRxiv · Aug 13, 2024 · PreprintBioengineering