Roberto Plebani

Human fallopian tube-on-a-chip for preclinical testing of non-hormonal contraceptives with living human sperm

The paper develops a human fallopian tube-on-a-chip model to test non-hormonal contraceptives, showing dose-dependent sperm motility inhibition by TDI-11861.

Induction of cervical dysfunction associated with preterm birth by IL-1 and dysbiotic microbiome revealed in human endocervix chips

The paper uses human endocervix chips to show that IL-1 receptor antagonists may prevent preterm labor by reducing cervical dysfunction.

Exacerbation of influenza virus induced lung injury by alveolar macrophages and its suppression by pyroptosis blockade in a human lung alveolus chip

This study shows that alveolar macrophages worsen influenza-induced lung injury in a human lung alveolus chip, but blocking pyroptosis reduces inflammation and tissue damage.

Skeletal Muscle Mitochondrial Dysfunction Mediated by Pseudomonas aeruginosa Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted Compounds

This study investigates how Pseudomonas aeruginosa's MvfR quorum sensing transcription factor disrupts mitochondrial function in skeletal muscle and shows that inhibiting MvfR or using mitochondrial-targeted compounds can reverse these effects.