Perivascular matrix densification dysregulates angiogenesis and activates pro-inflammatory endothelial cells
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole A. Parent, Xudong Fan, , Brendon M. Baker
This study shows that perivascular matrix densification promotes fibrosis by activating pro-inflammatory endothelial cells through a novel VE-cadherin-TGF-βR2 axis.
Advanced Science · Jun 17, 2026Peer-reviewedBioengineering