Author

Jingyi Xia

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:spatial domain detection· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Brendon M. BakeriD· 3 shared A Gupta· 1 shared Adam C. AbrahamiD· 1 shared Ariella ShikanoviD· 1 shared Avinava RoyiD· 1 shared Carole A. ParentiD· 1 shared Christopher D. DavidsoniD· 1 shared Claudia LoebeliD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBioengineering

Brendon M. BakerORCID

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Author profile →

4 papers

Recent·Most cited

A 3D image atlas chronicling cellular and structural dynamics following lung injury identifies the aberrant expansion of endothelial cells that fail to form perfused vasculature

Jingyi Xia, A Gupta, Ethan Poupard, Hayden Helms, Brendon M. Baker

This paper creates a 3D image atlas of lung injury dynamics in mice, identifying aberrant endothelial cell expansion that fails to form perfused vasculature as a key feature of pulmonary fibrosis.

bioRxiv · Jul 23, 2026 · PreprintBioengineering

Perivascular matrix densification dysregulates angiogenesis and activates pro-inflammatory endothelial cells

Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole A. Parent, Xudong Fan, , Brendon M. Baker

This study shows that perivascular matrix densification promotes fibrosis by activating pro-inflammatory endothelial cells through a novel VE-cadherin-TGF-βR2 axis.

Advanced Science · Jun 17, 2026Peer-reviewedBioengineering

SpatialESD: spatial ensemble domain detection in spatial transcriptomics

Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui

SpatialESD improves spatial domain detection in spatial transcriptomics by integrating multiple methods and capturing both direct and indirect relationships between clusters.

Advanced Science · Feb 12, 2026Peer-reviewedBioinformatics

Local photo-crosslinking of native tissue matrix regulates cell function

Donia W Ahmed, Matthew L. Tan, Yuchen Liu, Jackson Gabbard, Esther Gao, Avinava Roy, Michael M. Hu, Firaol S. Midekssa, Miriam Stevens, Fulei Wuchu, Minal Nenwani, Jingyi Xia, Adam C. Abraham, Deepak Nagrath, Lin Han, , Claudia Loebel

This study uses photo-crosslinking to induce early fibrotic changes in ex vivo tissue, showing how matrix stiffening affects cell behavior and fibrosis progression.

Nature Materials · Sep 5, 2025Peer-reviewedBioengineering