Carole A. Parent

The paper introduces an optimized differentiation protocol for HL60 cells to generate neutrophil-like cells with improved morphology and functionality compared to traditional methods.

This study shows that perivascular matrix densification promotes fibrosis by activating pro-inflammatory endothelial cells through a novel VE-cadherin-TGF-βR2 axis.

This study shows KRT16 inhibits type I interferon signaling and innate immunity in skin diseases, providing new insights into inflammatory skin disorder mechanisms.

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

This study identifies two spatially distinct myosin II architectures in neutrophils that coordinate protrusion dynamics and directional persistence during migration.

This study shows cPLA2α localizes to exosomes during neutrophil chemotaxis, linking nuclear deformation to LTB4 signaling and motility.

This study shows that TGFβ1-TNFα-induced neutrophil chemokine secretion in breast tumor cells occurs independently of EMT.

This study shows neutrophils release nuclear DNA via exosomes to resolve sterile inflammation, with implications for treating inflammatory diseases.